Probing the signaling requirements for naive human pluripotency

Our paper investigating the signaling requirements for naive human pluripotency by high-throughput chemical screening was published today in Cell Reports. We report that naive hESCs can be maintained by blocking distinct nodes in the FGF signaling pathway and that dual MEK/ERK inhibition promotes efficient primed-to-naive resetting in combination with Activin A. This study was a collaboration between Washington University School of Medicine, the Novartis Institutes for Biomedical Research, and the Whitehead Institute for Biomedical Research