Laura Fischer receives NSF GRFP honorable mention

Laura Fischer, a second-year Ph.D. student in the Theunissen lab, has received an honorable mention from the National Science Foundation’s (NSF) 2020 Graduate Research Fellowship Program (GRFP).

The program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering, and mathematics disciplines who are pursuing research-based master’s and doctoral degrees at accredited United States institutions.

Kudos to Laura. We’re looking forward to your exciting studies!

Trophoblast stem cells derived from naive human stem cells

Our paper examining the trophoblast potential of distinct human stem cell states was published today in eLife. We report that naive, but not primed, human pluripotent stem cells (hPSC) can directly differentiate into trophoblast stem cells (TSC). The derivation of TSCs from naïve hPSCs presents a new model system to elucidate early mechanisms  governing placental development and associated pathologies. This study was a collaboration with the Solnica-Krezel, Wang and Kommagani labs at Washington University.

Image of naive hPSC-derived human TSCs stained with a KRT7 antibody by Chen Dong (Theunissen Lab).