Paper on transposable elements and KRAB zinc-finger proteins

We are excited to contribute to a new study from the Trono laboratory in Lausanne, Switzerland (Pontis et al., Cell Stem Cell, 2019). This work describes how hominoid-specific transposable elements control transcription in naive hESCs and during embryonic genome activation, activating evolutionarily recent KRAB zinc-finger proteins that in turn ‘tame’ the activity of the transposons.